um azide, nordihydroguaiaretic acid but not by dapsone,
aminotriazole or indomethacin. Those results suggested
us the potential participation in this biotransformation of
an oxidase or a peroxidase but not of lactoperoxidase or
cyclooxygenase
. We were unable to detect the formation of either hydroxyl or 1-hydroxyethyl radicals in those
studies. In the course of following studies performed at
the opportunity in rats exposed to a standard Lieber and
De Carli diet for 28 d, we observed the induction not
only of XOR cytosolic activation pathways but also of
the microsomal one