This chapter deals with the various chemical contaminants such as pesticide residues, heavy metals and radionuclides, veterinary drugs and antibiotics, mycotoxins, nitrates and nitrites, detergents and disinfectants present in milk and milk products. Apart from reviewing the extent and level of contamination through these chemicals in different places and countries, this chapter also discusses the health impacts of the contaminants, various sources of contamination, analytical techniques, regulatory aspects and methods to manage the contaminants