Insulinoma is a functional tumor derived from pancreatic
β cells characterized by autonomous insulin secretion. With
an incidence of around 1 to 4 per million persons, insuli-
noma presents with hypoglycemic symptoms caused by the
overproduction of insulin (1, 2). The disease is distinguished
by the onset of central nervous system (CNS) symptoms
upon fasting, including impaired consciousness, convulsions
and abnormal behavior (3, 4). Radical treatment for insuli-
noma generally consists of surgical resection, although phar-
macotherapy is usually selected if tumor localization or sur-
gical resection prove difficult due to the presence of multi-
ple complications or if the patient does not wish to undergo
surgery, as in the present case (5). This report describes our
experience in treating a patient with chronic renal failure
and a history of diabetes mellitus who developed insulinoma
and chose to receive pharmacotherapy with diazoxide. There
is no current literature regarding the treatment of dialysis
patients with diazoxide. We therefore present this very rare
case in which we carefully monitored the patient’s blood