Fig. 3. Multiple alignment of the deduced amino acid sequences of SmekCatB with other cathepsin B sequences. The amino acid sequences of SmekCatB with other cathepsinB sequences showing highly conserved amino acids by grey and black outlines. The asterisk (*) indicates identical amino acids, two dots (:) indicates conserved aminoacid substitutions and dot (.) indicate semi-conserved amino acid substitutions. The thiol consensus pattern is indicated by as ( ); active site residues, (); cysteine
residues involved in disulfide bonding, (•). Smek: Schistosoma mekongi; Sj: Schistosoma japonicum; Sm: Schistosoma mansoni; Fg: Fasciola gigantica; Fh: Fasciola hepatica;
Ov: Opisthorchis viverrini. KP317840 (unpublished); CAA50305.1 (Merckelbach et al., 1994); CAD44624.1 (Sajid et al., 2003); CAC85211.2 (Caffrey et al., 2002); AAO73002.1
(Meemon et al., 2004); ABU62925.1 (unpublished) and ACT99885.1 (Sripa et al., 2010) are accession numbers of cathepsin B sequences available from GenBankTM.