Given its reputation for neuroprotective and cerebrovascular effects, ginkgo may be most useful for depressive symptoms associated with and/or resulting from vascular events. This type of mood disorder, due to a general medical condition, Table 40.1 Saint John’s wort (SJW)–drug interactions 1. SJW decreases the blood concentrations of the following agents: Anticancer drugs: irinotecan and its active metabolite SN-38 Anticoagulants: phenprocoumon and warfarin Antidepressants: