A closed-loop Six Sigma mechanism was proposed to achieve high reliability performance of complex electronics equipment in the context of distributed supply chain environment. The life cycle for these products is relatively short while the time-to-market plays a substantial role in the market share. The Six Sigma program was driven by the customer satisfaction along with the enticement of warranty cost savings. DMAIC steps are embedded into the closed loop closed loop model forming a continuous loop to drive the corrective actions. A cross-functional team is formed by drawing managers, engineers, and technicians both vertically and horizontally across multiple departments. The team is able to devise a quick Six Sigma solution and to achieve the goal through the execution of DMAIC procedures. Finally the proposed model was demonstrated on the reliability deployment of the PCB manufacturing chain in the semiconductor testing industry. The objective was achieved by reducing the infant mortality of PCBs through the implementation of HASS and power cycle tests in the upper stream subcontract manufacturing stage. This enables the product failure rate to be reduced by 50%, resulting in an annual cost saving of $746,389. Current work only focuses on the warranty reduction benefitted from the Six Sigma program. Future research will extend the analysis to the product life cycle cost versus the implementation of Six Sigma programs.