ADH activity in the presence of alprazolam and flunitrazepam. The presence of alprazolam (1.0 mM) and flunitrazepam (0.04 mM) in the reaction media induced a decrease in ADH activity (45.1, 39.8 and 29.5 mU/mg prot for control, alprazolam and flunitrazepam, respectively). Results are expressed as percentage of control and as mean ± SEM of six independent experiments. ⁄⁄P 6 0.05, ⁄⁄⁄P 6 0.0001