Dengue fever, also known as breakbone fever, is a viral disease characterized by severe headache, skin rash and debilitating muscle and joint pain. Recent studies estimate ~390 million new infections every year, some of which progress to more severe forms of the disease, characterized by circulatory failure, shock, coma and death. The disease is caused by any of four dengue virus serotypes, and is transmitted to humans by the Aedes aegypti mosquito, which has regained global distribution in the tropical and subtropical regions of the globe. Currently, there is no vaccine to protect against dengue, and there is consensus on the urgent need for effective dengue vaccines, not only for those who live in endemic areas, but also for those who travel or are deployed to those areas