The population of the Zambezi river valley is estimated to be about 32 million. About 80% of the population of the valley is dependent on agriculture, and the upper river's flood plains provide good agricultural land.
Communities by the river fish it extensively, and many people travel from far afield to fish. Some Zambian towns on roads leading to the river levy unofficial 'fish taxes' on people taking Zambezi fish to other parts of the country. As well as fishing for food, game fishing is a significant activity on some parts of the river. Between Mongu and Livingstone, several safari lodges cater for tourists who want to fish for exotic species, and many also catch fish to sell to aquaria.