The establishment of a functional vascular system is crucial during
organ development as well as during tissue repair. In bone, blood vessels
not only serve as a source of oxygen and nutrients, but also supply
calcium and phosphate, the building blocks for mineralization. In
addition, blood vessels in the bone marrow appear to have a major role
as a niche for both the bone-forming skeletal stem cells and bloodforming
hematopoietic stem cells [1]. The connection between
angiogenesis and osteogenesis is also evident during the healing of
bone fractures, as a timely and coordinated angiogenic response is of
vital importance for successful bone repair [2]. Increasing insight into
the molecular and cellular processes orchestrating the angiogenic
cascade may help to develop novel treatments for fracture healing,
especially for clinical situations with a limited angiogenic host response
such as large bone defects or fractures with severe soft tissue trauma. In
The establishment of a functional vascular system is crucial duringorgan development as well as during tissue repair. In bone, blood vesselsnot only serve as a source of oxygen and nutrients, but also supplycalcium and phosphate, the building blocks for mineralization. Inaddition, blood vessels in the bone marrow appear to have a major roleas a niche for both the bone-forming skeletal stem cells and bloodforminghematopoietic stem cells [1]. The connection betweenangiogenesis and osteogenesis is also evident during the healing ofbone fractures, as a timely and coordinated angiogenic response is ofvital importance for successful bone repair [2]. Increasing insight intothe molecular and cellular processes orchestrating the angiogeniccascade may help to develop novel treatments for fracture healing,especially for clinical situations with a limited angiogenic host responsesuch as large bone defects or fractures with severe soft tissue trauma. In
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