The prominent IgE response againt helminth infection, that is predominantly polyclonal, has been suggested to play a role in the down-modulation of skin reactivity to allergens through the saturation of high-affinity IgE receptors (FcεRI) on
mast cells, thus limiting the potential for interaction between allergens and specific IgE on mast cells. However, it has been shown that interference of allergen specific response by polyclonal IgE only occurs at very high levels of IgE that are considered not to be commonly present in human populations . We have tested this hypothesis by analyzing the correlation between levels of total IgE with skin test reactivity determined by wheal size; however, as the total IgE positive children of our study presented in general medium to low levels of total IgE we did not found a negative association between these outcomes.