This study demonstrated that active CMC–PVOH films can be prepared by incorporation of clove oil. Addition of PVOH led to improvement in mechanical and permeability properties of film. The films improved the shelf life of ground chicken meat during refrigerated storage. These films were also effective in inhibiting inoculated Gram-positive food pathogens in meat thereby enhancing the safety of meat. The CMC–PVOH–clove oil films have potential as alternate active packaging material for meat preservation. Further research on feasibility of such films in improving quality and safety of commercial meat products is needed.