Peptic ulcer disease is often associated with Helicobacter pylori infection (75 to 95 percent of duodenal ulcers and 65 to 95 percent of gastric ulcers)," although most patients do not know their H. pylori sta- tus. In addition, many patients with ulcer disease and serology findings negative for H. pylori report recent use of nonsteroidal anti-inflammatory drugs. Other symptoms of peptic ulcer disease include concurrent, episodic gnawing or burning pain; pain relieved by food; and nighttime awakening with pain.