NO is a key regulator in vascular integrity. Recently a fundamentally different pathway for NO generation in addition to the classical NO synthase-dependent pathway has been described. NO can be generated from inorganic nitrate and nitrite, abundantly found in green leafy vegetables [7] and [8]. In humans, after absorption in the upper gastrointestinal tract, approximately 25% of circulating nitrate is actively taken up by the salivary glands and is concentrated up to 20-fold in saliva.