This research looks at the work of Margaret C. Anderson, the editor of the Little Review. The review published first works by Sherwood Anderson, James Joyce, Wyndham Lewis, and Ezra Pound. This research draws upon mostly primary sources including memoirs, published letters, and a complete collection of the Little Review. Most prior research on Anderson focuses on her connection to the famous writers and personalities that she published and associated with. This focus undermines her role as the dominant creative force behind one of the most influential little magazines published in the 20th Century. This case example shows how little magazine publishing is arguably a literary art.