Regardless of the format used, HQG or conventional PR, rehabilitation exercise produces positive effects on health, subjective symptoms, and functions among patients suffering from COPD. This study solidifies the concept that rehabilitation is essential in the management of COPD. Moreover, this study contributes further evidence to support HQG as an alternative form of exercise for COPD patients that should be considered to suit individual factors (e.g., severity of airflow limitation, cost, interest, perceived benefits), especially when the ultimate management goal is to promote long-term exercise habits. This study also highlights areas for future studies—e.g., anti-inflammatory effect of HQG among muscle-wasted patients with COPD, potential effect of HQG to relieve dyspnea.