Atpresent, we know that numerous co- and post-translational modifica-tions, and molecular interactions involving distinct aquaporin isoformsand regulatory proteins act, together with signaling intermediatessuch as cytosolic H+and Ca2+, to regulate aquaporin gating and sub-cellular trafficking. However, these mechanisms often need to be placedin their genuine cellular context. The upstream signaling events andtheir cross-talks during plant cell response to hormone or environmen-tal stimulations are also largely unknown