Medications
Subjects in the two bupropion groups received 150-mg tablets of sustained-release bupropion (Zyban, Glaxo Wellcome), and all other subjects received identical-appearing tablets. In the bupropion groups, subjects received 150 mg of bupropion in the morning and a placebo tablet in the evening on days 1, 2, and 3 of treatment; and one bupropion tablet in the morning and one in the evening on days 4 to 63. All other subjects took placebo tablets twice daily from days 1 to 63. Subjects in the nicotine-patch groups used one patch (Habitrol, Novartis Consumer Health) per day for eight weeks beginning on the quitting day (day 8). All other subjects applied a placebo patch each day for eight weeks. The patches used from weeks 2 to 7 each contained 21 mg of nicotine; those used during week 8 each contained 14 mg, and those used during week 9 each contained 7 mg.
MedicationsSubjects in the two bupropion groups received 150-mg tablets of sustained-release bupropion (Zyban, Glaxo Wellcome), and all other subjects received identical-appearing tablets. In the bupropion groups, subjects received 150 mg of bupropion in the morning and a placebo tablet in the evening on days 1, 2, and 3 of treatment; and one bupropion tablet in the morning and one in the evening on days 4 to 63. All other subjects took placebo tablets twice daily from days 1 to 63. Subjects in the nicotine-patch groups used one patch (Habitrol, Novartis Consumer Health) per day for eight weeks beginning on the quitting day (day 8). All other subjects applied a placebo patch each day for eight weeks. The patches used from weeks 2 to 7 each contained 21 mg of nicotine; those used during week 8 each contained 14 mg, and those used during week 9 each contained 7 mg.
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