Hydrochlorothiazide
Hydrochlorothiazide is an established thiazide diuretic. Thiazides affect the renal tubular
mechanisms of electrolyte reabsorption, directly increasing excretion of fluid, sodium Early Tolerance Studies
Oral and intravenous (i.v.) eprosartan was safe and well tolerated in healthy subjects when given
single oral doses ≤800 mg, single i.v. doses ≤20 mg, and repetitive oral doses≤300 mg twice
daily for 8 days. Oral eprosartan was safe and well tolerated in patients with essential
hypertension at repetitive oral doses of ≤1200 mg once daily for 1 week and in patients with
renal insufficiency at repetitive oral doses of 300 mg twice daily for 7 days. The most common
adverse experiences following eprosartan dosing were headache, dizziness and fatigue. There
appeared to be no gross differences in the frequency of adverse experiences following eprosartan
dosing compared to placebo with the exception of headache which was reported more frequently
following eprosartan dosing than following placebo dosing.