Hepatitis E is uncommon in North America and Western
Europe, but has been documented to masquerade as DILI.
Dalton and colleagues suggested a 12% acute hepatitis E rate
in 47 cases thought to be DILI from the United Kingdom and
New Zealand based on hepatitis E virus (HEV) IgG and IgM
serologies.60 The DILIN retrospectively searched its registry
for evidence of acute hepatitis E in 318 cases. All nine cases
with positive HEV serologies were tested for HEV RNA, and
re-evaluated by the DILIN group for likelihood of DILI versus
HEV. Seven (2%) were felt to be more likely acute hepatitis E