Despite these documents and numerous existing RCTs, the efficacy and/or safety of many modifications of infant feeding remain(s) questionable [14]. This is mainly due to the methodological limitations of many of the trials. One such example could
be infant formulas supplemented with probiotics and/or prebiotics. In the position
paper recently published by the ESPGHAN Committee on Nutrition [15], it was
noted that interpreting studies on the effects of probiotic supplementation of infant
formula on growth is difficult due to the limited number of studies that analyzed the
effects of a given probiotic strain. The studies were often too small with insufficient
power to identify relevant effects on growth, and the follow- up periods in the trials
were short. Although, in general, it was concluded that a few probiotic strains used
to supplement infant formula support normal growth in healthy term infants, this
conclusion needs to be considered with caution. The same caution applies to other
outcomes.
Despite these documents and numerous existing RCTs, the efficacy and/or safety of many modifications of infant feeding remain(s) questionable [14]. This is mainly due to the methodological limitations of many of the trials. One such example could be infant formulas supplemented with probiotics and/or prebiotics. In the position paper recently published by the ESPGHAN Committee on Nutrition [15], it was noted that interpreting studies on the effects of probiotic supplementation of infant formula on growth is difficult due to the limited number of studies that analyzed the effects of a given probiotic strain. The studies were often too small with insufficient power to identify relevant effects on growth, and the follow- up periods in the trials were short. Although, in general, it was concluded that a few probiotic strains used to supplement infant formula support normal growth in healthy term infants, this conclusion needs to be considered with caution. The same caution applies to other outcomes.
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