Simian-human immunodeficiency virus

Simian-human immunodeficiency viruses(SHIVs)thatmirrornaturaltransmitted/founder(T/F)viruses
in manareneededforevaluationofHIV-1vaccinecandidatesinnonhumanprimates.Currentlyavailable
SHIVs containHIV-1 env genes fromchronically-infectedindividualsanddonotreflect thecharacter-
istics ofbiologicallyrelevantHIV-1strainsthatmediatehumantransmission.Wechosetodevelopclade
C SHIVs,ascladeCisthemajorinfectingsubtypeofHIV-1intheworld.Weconstructed10cladeCSHIVs
expressingEnvproteinsfromT/Fviruses.ThreeofthesetencladeCSHIVs(SHIVKB9C3,SHIVKB9C4
and SHIVKB9C5)replicatedinnaïverhesusmonkeys.ThesethreeSHIVsaremucosallytransmissible
and areneutralizedbysCD4andseveralHIV-1broadlyneutralizingantibodies.However,likenaturalT/F
viruses, theyexhibitlowEnvreactivityandaTier2neutralizationsensitivity.Ofnote,noneofthecladeC
T/F SHIVseliciteddetectableautologousneutralizingantibodiesintheinfectedmonkeys,eventhough
antibodies thatneutralizedaheterologousTier1HIV-1weregenerated.Challengewiththesethreenew
clade CSHIVswillprovidebiologicallyrelevanttestsforvaccineprotectioninrhesusmacaques

ผลลัพธ์ (ไทย) 1:

ไวรัสเอชไอวีสิมิลันมนุษย์ไวรัส (SHIVs) thatmirrornaturaltransmitted/founder(T/F)ใน manareneededforevaluationofHIV-1vaccinecandidatesinnonhumanprimates.CurrentlyavailableSHIVs env containHIV 1 ยีน fromchronically-infectedindividualsanddonotreflect thecharacter-istics ofbiologicallyrelevantHIV-1strainsthatmediatehumantransmission.WechosetodevelopcladeC SHIVs, ascladeCisthemajorinfectingsubtypeofHIV-1intheworld.Weconstructed10cladeCSHIVsexpressingEnvproteinsfromT/Fviruses.ThreeofthesetencladeCSHIVs (SHIVKB9C3, SHIVKB9C4และ SHIVKB9C5) replicatedinnaïverhesusmonkeysThesethreeSHIVsaremucosallytransmissibleและ areneutralizedbysCD4andseveralHIV-1broadlyneutralizingantibodies.However,likenaturalT/Fไวรัส theyexhibitlowEnvreactivityandaTier2neutralizationsensitivity.Ofnote,noneofthecladeCT/F SHIVseliciteddetectableautologousneutralizingantibodiesintheinfectedmonkeys งามแอนตี้ thatneutralizedaheterologousTier1HIV-1weregenerated.Challengewiththesethreenewclade CSHIVswillprovidebiologicallyrelevanttestsforvaccineprotectioninrhesusmacaques

ผลลัพธ์ (ไทย) 2:

ไวรัสโรคภูมิคุ้มกันบกพร่องเหมือนลิงมนุษย์ (SHIVs) thatmirrornaturaltransmitted / ผู้ก่อตั้ง (T / F) ไวรัส
ใน manareneededforevaluationofHIV-1vaccinecandidatesinnonhumanprimates.Currentlyavailable
SHIVs containHIV-1 ยีน env fromchronically-infectedindividualsanddonotreflect thecharacter-
istics ofbiologicallyrelevantHIV 1strainsthatmediatehumantransmission.Wechosetodevelopclade-
C SHIVKB9C5) replicatedinnaïverhesusmonkeys.ThesethreeSHIVsaremucosallytransmissible และ areneutralizedbysCD4andseveralHIV-1broadlyneutralizingantibodies.However, likenaturalT / F ไวรัส theyexhibitlowEnvreactivityandaTier2neutralizationsensitivity.Ofnote, noneofthecladeC T / F SHIVseliciteddetectableautologousneutralizingantibodiesintheinfectedmonkeys, แม้ว่าแอนติบอดี thatneutralizedaheterologousTier1HIV-1weregenerated.Challengewiththesethreenew clade CSHIVswillprovidebiologicallyrelevanttestsforvaccineprotectioninrhesusmacaques

ผลลัพธ์ (ไทย) 3:

ลิงไวรัสภูมิคุ้มกันบกพร่องของมนุษย์ ( shivs ) thatmirrornaturaltransmitted / ผู้ก่อตั้ง ( T / F ) ไวรัส
ใน manareneededforevaluationofhiv-1vaccinecandidatesinnonhumanprimates . currentlyavailable
shivs containhiv-1 Env ยีน fromchronically infectedindividualsanddonotreflect thecharacter -

C shivs พื้นฐาน ofbiologicallyrelevanthiv-1strainsthatmediatehumantransmission . wechosetodevelopclade ,ascladecisthemajorinfectingsubtypeofhiv-1intheworld . weconstructed10cladecshivs
expressingenvproteinsfromt / fviruses . threeofthesetencladecshivs ( shivkb9c3 และ shivkb9c4
, shivkb9c5 ) replicatedinna ไต verhesusmonkeys . thesethreeshivsaremucosallytransmissible
และ areneutralizedbyscd4andseveralhiv-1broadlyneutralizingantibodies อย่างไรก็ตาม likenaturalt / F
ไวรัสtheyexhibitlowenvreactivityandatier2neutralizationsensitivity . ofnote noneofthecladec
, t / F shivseliciteddetectableautologousneutralizingantibodiesintheinfectedmonkeys แม้

clade cshivswillprovidebiologicallyrelevanttestsforvaccineprotectioninrhesusmacaques challengewiththesethreenew แอนติบอดี thatneutralizedaheterologoustier1hiv-1weregenerated .