It is now clear that the use of a 3-year time horizon in our previous within-trial economic analysis resulted in a higher cost per QALY gained than the current analysis, which used a 10-year time horizon (6). With a 3-year time horizon, treatment costs were higher, and the benefits of lifestyle and metformin in terms of averted diabetes were less. The costs of both lifestyle and metformin were greatest in year 1, decreased substantially in years 2 and 3, and decreased further during years 4 through 10. In
contrast, much of the benefit of both lifestyle
and metformin, as assessed by both cumulative, nonintervention-related direct medical costs and quality of life, occurred after 3 years of follow-up.
It is now clear that the use of a 3-year time horizon in our previous within-trial economic analysis resulted in a higher cost per QALY gained than the current analysis, which used a 10-year time horizon (6). With a 3-year time horizon, treatment costs were higher, and the benefits of lifestyle and metformin in terms of averted diabetes were less. The costs of both lifestyle and metformin were greatest in year 1, decreased substantially in years 2 and 3, and decreased further during years 4 through 10. Incontrast, much of the benefit of both lifestyleand metformin, as assessed by both cumulative, nonintervention-related direct medical costs and quality of life, occurred after 3 years of follow-up.
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