2.1. Participants
We identified 1763 patients Z21 years of age admitted to the Beth Israel Deaconess Medical Center (BIDMC) between April 1, 1999 and October 31, 2008, with neurologist-confirmed acute ischemic stroke. The BIDMC is a 650-bed teaching hospital of Harvard Medical School designated as a primary stroke service hospital. We excluded patients with in-hospital strokes or transient ischemic attacks and we restricted analysis to patients living in the greater Boston metropolitan area (defined as living within 40 km of the hospital). This study was approved by the Committee on Clinical Investigations at BIDMC. Information on demographics, presenting symptoms, medical history and imaging results was abstracted from medical records at the time of hospitalization for stroke. Presumed stroke pathophysiology was characterized as: (1) large-artery atherosclerosis, (2) small-vessel occlusion, (3) cardioembolism, (4) other determined cause or (5) undetermined cause, using the approach developed for the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) (Adams et al., 1999).
2.1. ParticipantsWe identified 1763 patients Z21 years of age admitted to the Beth Israel Deaconess Medical Center (BIDMC) between April 1, 1999 and October 31, 2008, with neurologist-confirmed acute ischemic stroke. The BIDMC is a 650-bed teaching hospital of Harvard Medical School designated as a primary stroke service hospital. We excluded patients with in-hospital strokes or transient ischemic attacks and we restricted analysis to patients living in the greater Boston metropolitan area (defined as living within 40 km of the hospital). This study was approved by the Committee on Clinical Investigations at BIDMC. Information on demographics, presenting symptoms, medical history and imaging results was abstracted from medical records at the time of hospitalization for stroke. Presumed stroke pathophysiology was characterized as: (1) large-artery atherosclerosis, (2) small-vessel occlusion, (3) cardioembolism, (4) other determined cause or (5) undetermined cause, using the approach developed for the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) (Adams et al., 1999).
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