The current Canadian label registration for SmartFresh™ of apples allows multiple applications of 1-MCP, up to a maximum of four 1-MCP treatments at a concentration of 1 μL L−1 within 240 d of harvest. As a result, storage facilities can apply multiple 1-MCP treatments when storage rooms are being filled, or after a few months in storage. This has stimulated interest about the timing and application of multiple 1-MCP treatments with the possibility of enhancing fruit quality, as well as reducing the potential risk of storage-related disorders that are exacerbated by 1-MCP. Little information exists regarding the effect of multiple 1-MCP treatments on apple quality and disorder development, especially when treatments are applied to apples already stored in CA.