Results
At baseline and follow-up, A/A homozygotes had significantly higher weight and BMI
compared to C/C homozygotes. Though post exercise weight loss occurred, no significant
genotype by exercise interaction was found (Table 1). On account that the physical activity
recommendation is the minimal volume recommended for health benefits, exploratory analyses
restricted to the women who exercised at 100% and 150% of the recommendations revealed a
significantly larger loss of weight after 6 months for A/A homozygotes compared to carriers
of the C allele (Figure 1). The change in weight by rs8050136 genotype for all the participants
and those exposed to the three exercise durations is shown in the Supplementary Figure 1.