According to Louvre Curator Jean-Pierre Cuzin, "The entire history of portraiture afterwards depends on the Mona Lisa. If you look at all the other portraits – not only of the Italian Renaissance, but also of the seventeenth to nineteenth centuries – if you look at Picasso, at everyone you want to name, all of them were inspired by this painting. Thus it is sort of the root, almost, of occidental portrait painting."
In a break with the Florentine tradition of outlining the painted image, Leonardo perfected the technique known as sfumato, which translated literally from Italian means "vanished or evaporated." Creating imperceptible transitions between light and shade, and sometimes between colors, he blended everything "without borders, in the manner of smoke," his brush strokes so subtle as to be invisible to the naked eye.