Exposure to VC is associated with hepatomegaly and/or splenomegaly and with various histological lesions in the liver.
Vinyl chloride-induced liver damage includes the following features: hypertrophy and hyperplasia of hepatocytes, activation and hyperplasia of sinusoidal lining cells, fibrosis of the portal tracts and the septa and intralobular perisinusoidal regions, sinusoidal dilation and focal areas of hepatocellular degeneration.
Several studies are indicating the great similarity between the histological sequences in the liver of rodents exposed by inhalation to VC and the lesion observed in VC-exposed workers.