- Wheezing When airways become constricted, blocked, or inflamed, the lungs produce a wheezing or whistling sound when you breathe. Wheezing can be associated with multiple causes, some of which are benign and easily treatable. However, wheezing is also a symptom of lung cancer, which is why it merits your doctor’s attention. Don’t assume that wheezing is caused by asthma or allergies. Have your doctor confirm the cause.