The population of C. pavonana larvae from Pasirwangi district, Garut, West Java, was observed to be slightly resistant to profenofos because its resistance ratio (RR) value was more than one but less than five. Resistance ratio in feeding assay method was higher than dry film method indicating that the resistance mechanism involved may primarily occur in the alimentary canal of the insect. Field populations of C. pavonana were susceptible to tobacco leaf extract. Therefore, tobacco leaf extract could be used as an alternative insecticide for the management of C. pavonana resistance to profenofos insecticide.