The Genetic Diversity of PRSV
Knowledge of the genetic diversity of PRSV is important for
effective evidence-based disease management. The genetic
diversity of PRSV was observed in different regions of the
world [34]. PRSV isolates and the sequence for PRSV CP
genes have been presented in Table 1. Sequence diversity
among isolates of the virus and their distribution are important
for establishing virus origin, development, dispersion,
and disease etiology, in the pursuit of effective virus disease
management. There is little sequence variation among the
CP genes of PRSV isolates from the USA and Australia [35,
36]. On the other hand, there is greater sequence variation
amongst the CP genes of PRSV isolates from India [37]
and Mexico [38]. The diversity at amino acid and nucleic
acid levels was highest among the Asian population of
PRSV isolates [37]. The PRSV isolates from India differed
from the PRSV isolates from other countries. Bateson et al.
[39] reported that the origin of PRSV was South Asia and
found a greater diversity in PRSV isolates from India. The
differences in PRSV were observed due to differences in the
CP gene length [37].Thehighest diversity of PRSV nucleotide
sequences was found in the CP and HC-Pro genes collected
from India [40]. PRSV might have been transported from
India to America in the early 18th century and spread in 19th
and 20th centuries [40]. Variation in the CP gene sequences
of PRSV was observed in different parts of the world [35].The
genetic diversity of PRSV depends on geographical location.
For example, the transgenic papaya incorporating CP gene
(HA 5-1) isolated from USA showed resistance to PRSV
infection by the severe USA isolate (HA) but did not show
resistance against infection by theAustralian andThai isolates
of PRSV [34].
The Genetic Diversity of PRSVKnowledge of the genetic diversity of PRSV is important foreffective evidence-based disease management. The geneticdiversity of PRSV was observed in different regions of theworld [34]. PRSV isolates and the sequence for PRSV CPgenes have been presented in Table 1. Sequence diversityamong isolates of the virus and their distribution are importantfor establishing virus origin, development, dispersion,and disease etiology, in the pursuit of effective virus diseasemanagement. There is little sequence variation among theCP genes of PRSV isolates from the USA and Australia [35,36]. On the other hand, there is greater sequence variationamongst the CP genes of PRSV isolates from India [37]and Mexico [38]. The diversity at amino acid and nucleicacid levels was highest among the Asian population ofPRSV isolates [37]. The PRSV isolates from India differedfrom the PRSV isolates from other countries. Bateson et al.[39] reported that the origin of PRSV was South Asia andfound a greater diversity in PRSV isolates from India. Thedifferences in PRSV were observed due to differences in theCP gene length [37].Thehighest diversity of PRSV nucleotidesequences was found in the CP and HC-Pro genes collectedfrom India [40]. PRSV might have been transported fromIndia to America in the early 18th century and spread in 19thand 20th centuries [40]. Variation in the CP gene sequencesof PRSV was observed in different parts of the world [35].Thegenetic diversity of PRSV depends on geographical location.For example, the transgenic papaya incorporating CP gene(HA 5-1) isolated from USA showed resistance to PRSVinfection by the severe USA isolate (HA) but did not showresistance against infection by theAustralian andThai isolatesof PRSV [34].
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