After successful treatment, the RPR and VDRL tests usually become nonreactive after one year in patients with primary syphilis, after two years in patients with secondary syphilis, and after five years in latent syphilis .
Regardless, in some patients, particularly those treated inthe latent or late stages, nontreponemal antibodies can persist at a low titre for a long period of time, sometimes for life, and this is referred to as the “serofast reaction”