Drug resistance has become a major problem in the
treatment of tuberculosis around the globe. The risk factors
for resistance include previous treatment and interruption
of therapy. Drug resistance has developed very often
because of the inappropriately or poorly implemented
primary programs of tuberculosis control.1 Resistant mutants
to any single antibiotic occur readily at random in
bacilli undergoing replication and may be selected for by not
using the adequate combination of drugs. Management of
multidrug-resistant tuberculosis (MDR-TB) is usually very
complicated and treatment is successful in 60–70% of cases
only.2
The study documents that even 7-year long uninterrupted
individual treatment based on repeated susceptibility tests
did not prevent patient from the exitus letalis.