In our experiments,the
preincubation of arjunolic acid with Bothrops jararacussu venom
prevented the death of all animals,while oral pretreatment
decreased the lethality in more than 80%.Altogether,the neutralization of Bothrops jararacussu venom lethality by arjunolic acid
could be seen as the sum of the inhibition of each toxic activity.
However,despite the fact that the lethality potency assayis
well established as the gold standard in assessing the preclinical
efficacy of potential antiophidic substances