Breast cancer is one of the leading causes of cancer death
among women in worldwide [1]. Incidence rates are high in more
developed countries and low in less developed countries. In
Egypt, breast cancer is the most common cancer among women and representing 18.9% of total cancer cases [2]. As per
literature, the natural products derived from microorganisms
provide an excellent source of cancer medication [3]. Among
such microorganisms, Gram-positive actinomycete bacteria are
of special interest. They are known to produce chemically diverse
compounds with a wide range of biological activities [4–8]. From
the ecological point of view, several species of actinomycetes
(i.e., Streptomyces and Nocardiopsis) are frequently distributed
in marine environments such as oceans, rivers and seas. They
are dwelled in sponges, marine sediments, sea sands and water