In conclusion, the current study illustrated that administration of
ME that are rich in anthocyanins promoted age-dependent antioxidant protection and reduced oxidative stress-induced damage, as
shown by the hepatoprotective effect of mulberry in a spontaneously
aging mouse model. Antioxidant enzyme expression was shown to be
modulated through the up-regulation of ERK and down-regulation of
JNK and p38, thus promoting the activation of Nrf2. Furthermore,
supplementation with ME was observed to inhibit the accumulation
of Aβand improve learning and cognitive ability. Overall, mulberry is
able to protect against ageing-induced oxidative damage and
cognitive deficits; however, the physiological and molecular mechanisms underlying this conclusion warrant further investigation.
In conclusion, the current study illustrated that administration ofME that are rich in anthocyanins promoted age-dependent antioxidant protection and reduced oxidative stress-induced damage, asshown by the hepatoprotective effect of mulberry in a spontaneouslyaging mouse model. Antioxidant enzyme expression was shown to bemodulated through the up-regulation of ERK and down-regulation ofJNK and p38, thus promoting the activation of Nrf2. Furthermore,supplementation with ME was observed to inhibit the accumulationof Aβand improve learning and cognitive ability. Overall, mulberry isable to protect against ageing-induced oxidative damage andcognitive deficits; however, the physiological and molecular mechanisms underlying this conclusion warrant further investigation.
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