Not enough articles were available to separate
surgery types into those associated with mild, moderate,
and severe pain. Also, it was not possible to assess
statistically whether IV acetaminophen affected the incidence
of opioid side effects, because the end point was
either not reported (eg, postoperative nausea and vomiting
[PONV] not reported in n = 5 studies and pruritis
not reported in n = 13 studies), definitions differed (eg,
PONV on visual analog scale, nausea only, vomiting
only, or nausea and vomiting combined), or end points
occurred infrequently when measured such that the
trials were not appropriately powered to assess side
effect differences.
Not enough articles were available to separatesurgery types into those associated with mild, moderate,and severe pain. Also, it was not possible to assessstatistically whether IV acetaminophen affected the incidenceof opioid side effects, because the end point waseither not reported (eg, postoperative nausea and vomiting[PONV] not reported in n = 5 studies and pruritisnot reported in n = 13 studies), definitions differed (eg,PONV on visual analog scale, nausea only, vomitingonly, or nausea and vomiting combined), or end pointsoccurred infrequently when measured such that thetrials were not appropriately powered to assess sideeffect differences.
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