An 18-month-old boy has died of measles in an outbreak of the disease that has seen authorities in Berlin register more than 500 cases since October.
The boy died in hospital and it was not clear how he contracted the disease, Berlin's health senator Mario Czaja said on Monday.
The outbreak has sparked a debate over whether vaccinations against the disease should be made compulsory.
US authorities are also reporting more than 120 new cases in California.
The death of the young boy showed that measles continued to be a serious disease, Mr Czaja said. The disease is treatable but can weaken the immune system and cause lung and brain infections.