and uterine artery Doppler
US in the first trimester in 208 preeclamptic patients and
in 416 normal pregnancies; a significant reduction of
PP-13 level was shown in early preeclampsia but not in
late preeclampsia, with a PPV for early preeclampsia of
79% and 49% for late preeclampsia. Although PAPP-A
was reduced and uterine velocimetry Doppler was increased
in preeclampsia, the combination of these parameters
with PP-13 does not appear to improve the sensitivity
of PP-13[28