Ceftriaxone may precipitate in bile, causing biliary sludge, biliary pseudolithiasis, and gallstones, especially in children. It may cause allergic reactions similar to those caused by penicillin. Due to the 3-8% cross allergenicity with penicillins, caution should be used in those with a history of severe allergies to penicillin. Other common side effects include local irritation at the injections site, rash, and diarrhea. Hypoprothrombinaemia and bleeding are specific side-effects. Haemolysis is reported.[5][6][7] It has also been reported to cause post renal failure in children