Figure 1: Measured dose values for diff erent inhaled pMDI and DPI corticosteroids
Measured dose values are shown for label claim (or nominal dose), mean emitted dose, and mean fi ne particle dose
for the inhaled pMDI and DPI corticosteroids used in the Dose of Inhaled Corticosteroids with Equisystemic Eff ects
(DICE) trial by the National Institutes of Health and Asthma Clinical Research Network. Diff erences in the mass of
drug available from the various inhalers used in this study led to diff erences in clinical response. Data plotted from
Martin and colleagues;13 fi gure adapted from Dolovich.14 pMDI=pressurised metered-dose inhaler. DPI=dry powder
inhaler. *pMDIs used with Optichamber (Philips Healthcare, Andover, MA, USA), a valved holding chamber