Two-phase partitioning bioreactors use a nonbiodegradable, biocompatible and non-volatile organic solvent placed on top of an aqueous phase, which is aerated. A simplified diagram of the two-phase bioreactor is shown in Figure 3. These were developed for the high yield production of inhibitory products (21,221. Potential was later shown for the bioremediation of toxic compounds due to the systems' ability to supply sub-inhibitory amount of the toxic compound to the aqueous phase due to equilibrium considerations [21]