In a study by Payen et al. [24], patients with severe sepsis were
treated with CRRT at a relatively early stage, using the flow rate of
25 ml/kg/hr, but prognosis was not improved. However, Payen et al.
[24] carried out CRRT in patients with and without concurrent AKI.
When performed on septic patients showing no sign of AKI, CRRT
may actually increase renal damage