Results: The extract was standardized by HPLC to contain phyllanthin and hypophyllanthin. Nomortality was noted and the study exhibited no significant changes in general behavior, body weight, gross appearance of internal organs, hematological and biochemical parameters and the histological profile of liver also indicated the nontoxic nature of this drug. Biochemical studies showed no significant change in the levels of ALT, AST, albumin, triglycerides, cholesterol and albumin.