In the living cells some factors, as propionyl-L-carnitine, Coenzyme Q, nicotinamide, riboflavin and pantothenic acid, regulate biochemical processes of oxidative metabolism. Recent studies reported that administration of a co-formulation, HS 122.1, of these essential cofactors for 7 weeks improved muscular performance and induced an increase of food intake without an increase of body weight. These results suggest that HS 122.1 elicits an increase of food intake resulting in the intensification of the mithocondrial bioenergetic processes. In this study, in which the amount of food consumed by HS 122.1 supplemented rats was the same of controls, a significant decrease (P0.05; n