he interstitial space, where a lot of biological events take place, is the intelligent yard where cupping therapy exerts its biological talents. The role played by cupping therapy in mild or chronic myocardial ischemia such as recurrent angina and angina risk demonstrated in this study is promising and supports the concept that BLO cupping therapy is worthy of wider practical application and further accurate redetermination. It constitutes a motive for its employment in further grades of myocardial ischemia in future.