Mitragynine, concentration 250 micromolar, can inducer enzyme activity. N-demethylase but Inhibitor the activity of the enzyme Glutathione S-transferase. The results of this study conclude that Mitragynine has the potential to cause drug interactions with Glibenclamide, which is an N-demethylase inducer. Therefore, the use of modern medicine in conjunction with kratom to control blood sugar levels must be under supervision.