Abstract- Considering the high prevalence of osteoarthritis (OA) and since until now there has not been any
human studies to evaluate the effect of sesame in OA patients, this study was designed to assess the effect of
administration of sesame on inflammation and oxidative stress in patients with knee OA. Fifty patients with
knee OA were allocated into two groups namely control and sesame group. 25 patients in the control group
received 40 g placebo powder per day while 25 patients in the sesame group received 40 g of sesame seed
daily during two months of study along with standard medical therapy. Serum total antioxidant capacity,
malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were
measured. In the sesame group, a significant decrease in serum MDA and hs-CRP were seen after two months
of study (P0.05). Serum IL-6 decreased significantly in both groups compared with
baseline during the two-month study (P