Interferon (IFN) has been used sparingly in the treatment of low-grade SIL, but more research needs to be done on this methodology.244,245 The use of IFN for the treatment of SIL is inferior to surgical methods when cure rate is considered. The advantage to using IFN is that it does not deform the cervix or interfere with a normal pregnancy. Therefore it may be appropriate for use in selected females during the childbearing years.