Tn accordance with an embodiment of this invention a method of preparing a high yield Cissus Quadrangularis keto-sterone composition from a Cissus q. plant is disclosed. In a step of the method one or more roots of a Cissus q. plant are washed, dried and ground to a root powder. In other steps a first solvent is added to the root powder of the Cissus q.plant to provide a first mixture of root extracts and the first solvent followed by adding a second solvent to the first mixture to provide a second mixture comprising the first mixture and the second mixture. Substantially one or more keto-sterones of the first mixture is insoluble in the second solvent